Similac Advance Vs Pro Advance – Differences Explained

When it comes to infant formula, there are many different options on the market. Two of the most popular brands are Similac Advance and Pro Advance.

we will discuss the differences between Similac Advance vs Pro Advance?

Similac Advance and Similac Pro-Advance are both infant formulas produced by Abbott Laboratories. Similac Advance is a nutritionally complete formula that does not contain any added nutrients or prebiotics.

It can be a good choice for healthy, full-term infants without any specific nutritional needs. On the other hand, Similac Pro-Advance contains an exclusive blend of nutrients called OptiGRO, which is designed to support brain and eye development.

Similac Advance Vs Pro Advance

What Are Similac Advance And Pro Advance?

Both formulas, which are made by the Similac corporation, are available in liquid and powdered forms. These infant formulas have been created to mimic a mother’s breast milk as much as possible.

They also both have added iron for cognitive development and DHA & ARA (omega-3 & 6 fatty acids) for brain and eye health. 

Similac Advance and Similac Pro Advance are both lactose-free formulas, which means they are easy for babies to digest. They are also nutritionally complete formulas, so you can be sure your baby is getting everything they need to grow and develop properly. 

What Are The Main Ingredients Used In Similac Advance and Pro Advance?


It’s one of the omega-3s that people consume.


The majority of lutein is found in the human eye’s retina. The purple pigment lutein is an excellent antioxidant and may help prevent cancer in the future. Some researchers believe this is one of the best antioxidants for humans, along with other carotenoids like beta-carotene, zeaxanthin, and lycopene.

Vitamin E

Vitamin E is a skin-care ingredient that works to improve the appearance of the skin. Vitamin E aids in the maintenance of developing cells, giving rise to its reputation as a vitamin for producing healthy skin radiance.

Similac Advance Vs Pro Advance – Differences

Several immune-nourishing human milk oligosaccharides (HMOs) are found in breast milk. 

They encourage the formation of beneficial microorganisms in your infant’s digestive system, with 70% of the immune system concentrated there.

Similac’s first HMO, Alimentum, exclusively targeted breastfed babies until recently. It now aids in the maintenance of your child’s immune system in the same way that a breastfed baby does.

Pro Advance Doesn’t Contain Any GMO Ingredients

All of the dairy ingredients used are from cattle that have not been given artificial growth hormones. Many parents and nutritionists have praised non-GMO items because they are natural and devoid of chemicals or additives.

Non-GMO foods could provide the following advantages to your baby:

  • Doesn’t contribute to antibiotic resistance
  • Can preserve internal organs.

Price Difference

Similac Pro Advance is a somewhat costly formula, but it does give a lot of nutrition and an approximation as near to breastmilk as possible.

Similac Advance is less expensive than Similac Sensitive. However, I don’t believe the price difference is significant enough to sway parents.

The Smell Of Pro Advance Is Different From Similac Advance

Pro Advance has a distinct odor due to its sophisticated composition. It almost has a sharper fragrance. Although it’s not that apparent, it shouldn’t worry your baby.

In severe cases, they may start crying while eating formula.

Similac Advance Vs Pro Advance – Effect On Baby’s Sensitive Tummies

Similac Pro Advance contains a few distinct components, but both are designed to reduce spit-up, vomiting, and gas in newborns.

Similac Advance infant formula contains compounds that are helpful for some of the problems mentioned. However, infants who are overly sensitive and prone to allergies have been shown to develop mild allergies when fed this formula.

Pros And Cons Of Similac Advance And Pro Advance

Similac Advance

It will generate 5.3 fl oz of water with 100 calories, 2.07 grams of protein, 5.6 grams of fat, and 10.7 grams of carbohydrates in a serving size as prepared.


  • Provides a complete diet. Prebiotics are included.
  • There is no growth hormone or Palm olein oil in this baby formula.
  • Available in a ready-to-feed form.


  • On the pricey side, to be precise.
  • Has been linked to gas and fussiness in some babies.

Similac Pro Advance

It contains a unique combination of vitamins and minerals that are very similar to those found in human milk, including DHA, lutein, and vitamin E.


  • Suitable for newborns less than a year old.
  • Non-GMO, iron-fortified formula.
  • 2′ -FL HMO is included in the formula.


  • It might be tough to locate in a physical store.

Is Similac Pro Advance Better Than Similac Advance?

Both formulas are quite comparable, except for a few minor characteristics.

Because Pro Advance is non-GMO and includes the prebiotic 2’FL HMO present in breast milk, it has an advantage for some parents.

Is Similac Better Than Breast Milk?

Similac, Enfamil HCM, Enfamil Newborn, and other formula brands have excellent products that can help babies get the nutrition they require to develop and thrive when breast milk is unavailable. Breast milk, on the other hand, is regarded as the ideal choice if breastfeeding is doable. 

Other Similac Formulas – Similac Vs Enfamil

Similac Alimentum Formula Brand

It prevents choking. It’s also a hypoallergenic formula that claims to cure fussiness and colic in just 24 hours.

Enfamil Formulas

Enfamil Enspire

This formula is a fantastic alternative to Similac. This supplement, which has lactoferrin and is comparable to colostrum in terms of quantity, mimics the huge amounts of nutrition and advantages present in breast milk.

Enfamil NeuroPro

Similac infant formula, like Enfamil Premium, has all of the essential vitamins found in Enfamil baby formula and MFGM, which is a milk fat globule membrane.

Frequently Asked Questions

Q1: Can I feed Similac formula as well as breastfeed my baby?

Ans: Yes, you may accomplish this and provide your baby with the finest of both worlds in terms of both nutrition and movement.

Q2: Can I switch my baby from Similac Pro Advance to Similac Advance?

Ans: You may want further assistance from your child’s doctor. Since both formulations have nearly identical components, the change is feasible, although you might anticipate a few problems at first, depending on your child. For example, the modification might produce stomach issues, a different poop color, diarrhea, or even reflux.

Q3: What temperature should Similac Formulas be?

Ans: The ideal temperature for the solution should be approximately equal to or slightly lower than the body temperature. 96 degrees Fahrenheit ( 36 degrees Celsius ).

Q4: How long should I keep the formula after preparing it?

Ans: You must use powdered formula within 24 hours after mixing it.   

Q5: What is Similac Pro Advance good for?

Ans: The supplement Similac Pro Advance contains the 2’FL HMO, which is a milk-based formula for bottle-fed babies that provides complete nutrition for enhancing an infant’s immune system.

Q6: How long does it take for a baby to adjust to a formula change?

Ans: It generally takes 7-10 days for a baby to fully adjust to the new formula.

Q7: How do you make the Similac Advance Formula in a bottle?

Ans: Pour enough water into the baby bottle using the provided scoop. Place the dry scoop back in its container. Shake the bottle until all of the powder has dissolved before placing it on top of it with a cap.

Q8: Is Similac Advance good for babies who constipate?

Ans: Yes. Similac Advance has been demonstrated to aid in the development of soft feces in babies. One of the most common indications of constipation in infants is hard stool to pass.

Q9: How many bottles does a can of formula make?

Ans: A can of powdered formula will make around 40 ounces, which is 30-32 two-ounce bottles, or 16 four-ounce bottles.


We can say that Similac Advance is a great product for babies. With nearly identical ingredients, Similac Pro Advance is a great choice for parents who want to switch their baby’s formula. 

The only real difference between the two is that Similac Pro Advance contains the ingredient MFGM, which has been shown to provide some additional benefits for babies.

My name is Mark Joseph, and I’m on a mission to help new parents navigate the world of parenting. With over 5 years of experience as a parenting coach, I’m here to provide you with insight into all aspects of pregnancy, childbirth, and raising your newborn baby. Instagram Linkedln Facebook

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